TBJP's Cure-Coming is an ultra-absorbable curcumin for whole-body health support containing ultra-potent patented BCM-95® Curcumin which has been shown to aid in lowering systemic inflammation, boost brain/immune/digestive health as well as provide antioxidant support.

Curcumin, the bioactive component of Turmeric, Curcuma longa has an exceptionally wide spectrum of activities most notably it's antioxidant and anti-inflammatory properties. Most recently, it has also been postulated to have anti-depressive properties in major depressive patients as well as positive cognitive outcomes in older populations.

Curcumin inhibits pro-inflammatory transcription factors such as nuclear factor-kappa beta (NFK- B) which can effect joint inflammation. It also activates peroxisome proliferator–activated receptor gamma (PPAR-γ) and Nrf2 cell signalling pathways, leading to the downregulation of tumour necrosis factor (TNF) and interleukin-6 (IL-6), and upregulates adiponectin (the hormone involved in blood glucose and fatty acid breakdown made by adipose fat tissue).

In simple terms, curcumin has the potential to lower C-Reactive Protein (CRP; a measure of inflammation in the body), induce autophagy through mTOR inhibition (the selective destruction of damaged cellular organelles), protect against cardiac hypertrophy, and potentially decrease atherosclerosis risk.

Despite the promising nutritional and pharmacological properties of curcumin, it exhibits low aqueous solubility, poor gastrointestinal absorption and poor bioavailability.

It's high rate of metabolism, metabolic inactivation and rapid elimination from the body makes it difficult to yield appreciable plasma concentrations. Because of it's poor oral absorption, it is difficult for orally administered curcumin to reach blood levels sufficient to exert its bioactivities. Poor absorption from the gut and avid metabolism in the body is cited as reasons for the lack of systemic availability.

For these reasons, supplementation is necessary for those looking to increase their Curcumin intake by a meaningful margin.